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Journal of the Chinese Medical Association

Superoxide anion (O 2 ) is an important ROS and is formed by several enzymatic and non-enzymatic pathways (Figure 2)

4 Challenges and perspectives of ferroptosis in kidney diseases Ferroptosis, an iron-dependent regulated cell death driven by lipid peroxidation, has emerged as a central pathogenic mediator in kidney diseasesan organ uniquely susceptible to redox imbalance due to its high metabolic activity, abundant iron handling, and structural heterogeneity (276, 277)

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These enzymes were selected for further investigation, using UV-visible spectrophotometric enzyme activity assays, on the basis of their importance in mediating acetyl-CoA synthesis and transport into the mitochondria